Jérémie Bourdon ; Alban Mancheron - Statistical Properties of Similarity Score Functions

dmtcs:3502 - Discrete Mathematics & Theoretical Computer Science, January 1, 2006, DMTCS Proceedings vol. AG, Fourth Colloquium on Mathematics and Computer Science Algorithms, Trees, Combinatorics and Probabilities - https://doi.org/10.46298/dmtcs.3502
Statistical Properties of Similarity Score FunctionsArticle

Authors: Jérémie Bourdon ORCID1; Alban Mancheron ORCID1

  • 1 Laboratoire d'Informatique de Nantes Atlantique

In computational biology, a large amount of problems, such as pattern discovery, deals with the comparison of several sequences (of nucleotides, proteins or genes for instance). Very often, algorithms that address this problem use score functions that reflect a notion of similarity between the sequences. The most efficient methods take benefit from theoretical knowledge of the classical behavior of these score functions such as their mean, their variance, and sometime their asymptotic distribution in a given probabilistic model. In this paper, we study a recent family of score functions introduced in Mancheron 2003, which allows to compare two words having the same length. Here, the similarity takes into account all matches and mismatches between two sequences and not only the longest common subsequence as in the case of classical algorithms such as BLAST or FASTA. Based on generating functions, we provide closed formulas for the mean and the variance of these functions in an independent probabilistic model. Finally, we prove that every function in this family asymptotically behaves as a Gaussian random variable.


Volume: DMTCS Proceedings vol. AG, Fourth Colloquium on Mathematics and Computer Science Algorithms, Trees, Combinatorics and Probabilities
Section: Proceedings
Published on: January 1, 2006
Imported on: May 10, 2017
Keywords: average-case analysis,score functions,sequence comparison,[INFO.INFO-DS] Computer Science [cs]/Data Structures and Algorithms [cs.DS],[INFO.INFO-DM] Computer Science [cs]/Discrete Mathematics [cs.DM],[MATH.MATH-CO] Mathematics [math]/Combinatorics [math.CO]

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